Endocrine Abstracts

Background: In people with HIV on ARV treatment receiving Dolutegravir (DTG)-based regimen, weight and lipodystrophy have been reported.Aim: The aim of this is to evaluate the effect of DTG on the lipid profile and fat distribution on patients who have been switched from a non to a Dolutegravir (DTG)-based regimen on the lipid profile and fat distribution.Methods: One hundred patients above 18yrs of age were recruited into two arms...

Background: Adrenal insufficiency has been well established in patients with pulmonary tuberculosis in Nigeria. It has however not been well documented in patients with extra pulmonary TB. This study compared the adrenal function in patients with pulmonary TB vs those with extra pulmonary TB.Methods: We randomized 100 cases of pulmonary TB and 50 cases of diagnosed extra pulmonary TB, with the aim of assessing the adreno-cortical functions using both ser...

Background: The use of Dolutegravir (DTG) in the treatment of patients with HIV has been associated with reports of unexpected excess weight gain. The present study aimed to investigate the effect of DTG on the adrenal cortisol levels of HIV patients initiated on antiretroviral therapy (ART).Methods: Adult patients (≥18 years) newly initiated on ART were recruited into two groups (n-100 participants in each group). One group was initiated on a DTG-...

Background: The use of Dolutegravir (DTG) in the treatment of patients with HIV has been associated with reports of unexpected excess weight gain. The present study aimed to investigate the effect of DTG on the adrenal cortisol levels of HIV patients initiated on antiretroviral therapy (ART).Methods: Adult patients (≥18 years) newly initiated on ART were recruited into two groups (n-100 participants in each group). One group was initiated on a DTG-...

Background: The exposure to HAART has increased the chances of developing Diabetes among HIV patients. Hyperglycaemia is more common among those on Protease inhibitors (PI)-based regimens compared to other regimens. Glycated hemoglobin (HbA1c ) is now being recommended by the American Diabetes Association (ADA) for the screening of Diabetes because of convenience as it does not require fasting.Objective: We aimed to dete...

Background: The exposure to HAART has increased the chances of developing Diabetes among HIV patients. Hyperglycaemia is more common among those on Protease inhibitors (PI)-based regimens compared to other regimens. Glycated hemoglobin (HbA1c ) is now being recommended by the American Diabetes Association (ADA) for the screening of Diabetes because of convenience as it does not require fasting.Objective: We aimed to dete...

Introduction: The role of Vitamin D in bone formation and cardiovascular health could not be overemphasized. Sunlight is one of the principal sources of this vitamin/hormone. However, it’s deficiency has been observed in sunlight affluent areas. The objective of the study was to determine the prevalence and risk factors of low vitamin D among adults in the tropics (Kano).Methods: The study was a community-based cross-sectional descriptive study. The...

Background: We aimed to determine and compare the prevalence and associated factors of metabolic syndrome (MS) among HAART exposed versus HAART naïve HIV infected patients at the Aminu Kano Teaching Hospital, Kano (AKTH).Method: In this cross-sectional comparative study we evaluated 300 HIV infected persons who were divided into two age and sex matched groups – HAART-exposed and HAART-naïve – attending AKTH. MS was diagnosed using ATP...

Background: The lipid profile of healthy adults in northern Nigeria is scarcely reported in literature. Yet, hospital records show increasing frequency of dyslipidemia-related illnesses like CVA, MI, and peripheral vascular diseases in practice. We aim to report the pattern of lipid abnormalities in a rural population in Kano, Nigeria.Methods: A population screening of apparently healthy adults resident in sub urban community in Kano was undertaken over ...

Introduction: Lipid abnormalities are very common among HIV patients particularly those on Highly Active Antiretroviral Therapy (HAART). Infection with HIV causes decline in HDL cholesterol and a raise in triglyceride. Treatment with HAART causes Dyslipidaemia in a variety of ways.Aims: To determine the prevalence and factors associated with Dyslipidaemia among HAART naïve and HAART exposed HIV patients.Methodology: Three hund...